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  text: 'We'll consider two categories of vitamin D supplementation: below and above the recommended levels.\n\n1. What are the effects of vitamin D deficiency?\n-------------------------------------------------\n\n[17 One theoretical meta-analysis paper] shows that "several recent epidemiologic studies have demonstrated a strong association between vitamin D insufficiency and risk of cardiovascular disease, risk of diabetes and metabolic syndrome."\n\n[19 This population study] shows "low serum 25(OH)D levels are associated with a higher prevalence of PAD."\n\n**Conclusion**: If you are not getting the recommended dose of vitamin D, supplementation is advisable.\n\n2. What are the effects of vitamin D at and above the recommended levels?\n------------------------------------------------------------------------\n\nIt looks like the [1x effects on cancer prevention are dubious], although with more research we could find that it is effective on some types of cancer in particular. Likewise, its effect [1g on cardiovascular disease] seems nonexistent.  [1d Its effect on bone fracture] is negligible, although with slight potential to be significant at very high doses.\n\n**Conclusion**: supplementing vitamin D beyond recommended levels is unlikely to have significant effect. There is weak evidence that vitamin D can be harmful above recommended levels, so, overall, supplementation is around net neutral.',
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